Biology Colloquium - Dr. Laurent Dejean

Biology Colloquium - Dr. Laurent Dejean

Postby cdouglas » Tue Apr 28, 2015 1:50 pm

Department of Biology presents a seminar
Dr. Laurent Dejean
Assistant Professor of Chemistry
California State University, Fresno

"Bcl-2 family proteins: a direct regulatory link between cell survival and metabolism?"

Friday, May 1, 2015
3:00 - 4:00 PM
Science 2, room 109

It is now well established that shifts in energy metabolism are associated with cancer development and progression.
The most studied of these phenomena is the Warburg effect, which corresponds to an increase of anaerobic
glycolysis vs mitochondrial oxidative phosphorylation to produce energy for cellular processes. However, the
mechanisms related to these metabolic switches are still a matter of debate. Bcl-2 family proteins contain both pro-
(e.g. Bax), and anti-apoptotic (e.g. Bcl-2 and Bcl-xL) members which are respectively encoded by tumor suppressors
and proto-oncogenes. Up-regulation of the anti-apoptotic proteins Bcl-2 has been associated with Non-Hodgkin’s
lymphoma; and certain studies suggest that Bcl-2 plays a role in the regulation of energy metabolism. However, the
molecular players involved in this regulation are still to be defined. We recently observed that Bcl-2 or Bcl-xL
overexpression led to a significant increase of lactate production rates in a mouse pro-lymphocyte B cell line. This
phenomenon was associated with a stimulation of the lactate dehydrogenase (LDH) enzyme specific activity; and an
increase of the expression of the LDH-A subunit. Also, this phenotype was strongly attenuated if a Bcl-2 mutant of
interaction with Bax (Bcl-2-G145E) was overexpressed instead of native Bcl-2. These data suggest that Bcl-2/xL
expression levels may play an active role in stimulation of lactic fermentation commonly observed in blood cancer
cells; and that this effect may depend on the ability of these anti-apoptotic proteins to physically interact with Bax.



For further information: http://www.csufresno.edu/biology. If you need a disability-related accommodation or
wheelchair access, please contact Lindasue Garner at the Department of Biology at 278-2001 or e-mail
lgarner@csufresno.edu (at least one week prior to event).
cdouglas
 
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