Biology Colloquium

Biology Colloquium

Postby cdouglas » Thu Dec 13, 2012 11:24 am


Dr. Daniel Felmlee
Inserm Unit 748
Virus-host Interactions and Liver Disease

“Under a Lipoprotein Cloak; Hepatitis C Virus Uses
Host Triglyceride-Rich Lipoproteins to Infect
and Escape Host Defenses”

Monday, December 17, 2012
3:00-4:00 PM
Engineering East Building, Room 191

Approximately 160 million people worldwide (~ 3% of the population) are infected with hepatitis C virus (HCV). The natural course of HCV is to establish of a chronic infection, leading to chronic hepatitis and often leading to end-stage liver disease and hepatocellular carcinoma. Interestingly, HCV alters host hepatic lipid and lipoprotein metabolism to achieve its aims and promote its survival. Development of a vaccine for HCV has not been achieved, in part because HCV utilizes host lipoproteins to obscure itself from antibodies that would neutralize infection. The manipulation of host lipoproteins by HCV is a unique adaptation of this virus that has implications on interactions between metabolic parameters of an infected individual, such as diet, and HCV infection.

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