The seven departments of the College are housed in four buildings on the Fresno State Campus. They are as follows:
Additional facilities include:
- The Downing Planetarium in the Department of Physics hosts thousands of local area children and visitors each year.
- Jordan Research Center will be a 30,000 sq. ft. state-of-the-art research facility and will enable researchers from three colleges (Jordan College of Agriculture Sciences and Technology, College of Science and Mathematics, and the Lyles College of Engineering) to work side-by-side and create a new atmosphere of interconnectivity.
- The Moss Landing Marine Laboratory, located on the Central Coast, supports degree programs in marine biology.