Goto Research Group

 

Areas of Research

The Goto laboratory is focused on three major projects using fruit flies and human neuronal cultures to investigate neuronal function, oxidative stress and protein-protein interaction using biochemical, electrophysiological and locomotor behavioral methods. In particular the neurodegenerative diseases, amyotrophic lateral sclerosis-Parkinsonism dementia complex (ALS-PDC), Parkinson’s disease, and Alzheimer’s disease are investigated using fruit flies as a model system, human neuronal cultures are studied to elucidate protein-protein interactions using immunofluorescence and FRET microscoy, and oxidative stress in fruit flies and neurons are measured using traditional biochemical assays.

Recent Publications (for a complete list of publications)

(g = graduate co-author; u = undergraduate co-author)

  1. Kim B-H, Shin H-Y, Goto JJ, Carp RI, Choi E-K, Kim Y-S (2016) Cellular Prion Protein Combined with Galectin-3 and -6 Affects the Infectivity Titer of an Endogenous Retrovirus Assayed in Hippocampal Neuronal Cells. PLoS ONE 11(12): e0167293. doi:10.1371/journal.pone.0167293 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167293
  2. D. Zimmermang, J.J. Goto, V. V. Krishnan, “Equilibrium dynamics of Beta-N-Methylamino-L-alanine (BMAA) and its carbamate adducts at physiological conditions,” PLOS ONE, 2016, DOI:10.1371/journal.pone.0160491. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160491
  3. S.M. Gunasekarag, M.N. Hicksg, J. Park, C.L. Brooks, J. Serateu, C.V. Saundersg, S.K. Groverg, J.J. Goto, J-W. Lee, H. Youn, “Directed Evolution of the Escherichia coli cAMP Receptor Protein at the cAMP Pocket,” Journal of Biological Chemistry, doi:10.1074/jbc.M115.678474, 2015, 290 (44): 26587-26596.
  4. J.H. Koenig, J. J. Goto, K. Ikeda, “Novel NMDA Receptor-Specific Desensitization/Inactivation Produced by Ingestion of the Neurotoxins, Beta-N-methylamino-L-alanine (BMAA) or Beta-N-oxalylamino-L-alanine (BOAA/Beta-ODAP),” Comparative Biochemistry and Physiology, Part C: Toxicology and Pharmacology, 2015, Vol 167:43-50.
  5. R. J. Egusquizau, R. B. Runyonu, J. Ringelu, C. W. C. Seberu, G. Leyvau, J. Correau, C. D. Rolandu, M. Umaru, M. Xiao, J. T. Bushoven, J. J. Goto, “Calcium Oxalate Crystal Formation in Various Gravity Environments”, Gravitational and Space Research, 2014, 2(2):3-12.
  6. J.J. Goto, J. L. Koenig, K. Ikeda, “The Physiological Effect of ingested Beta-N-methylamino-L-alanine in a Glutamatergic Synapse in an in vivo Preparation”, Comparative Biochemistry and Physiology, Part C: Toxicology and Pharmacology, 2012, 156 (3-4):171-177.

Current Funding

  1. Louis Foundation; Amyloid Beta-Peptide Processing and BMAA
    $28,00 (2008-2017)
    Role: Principal Investigator
  2. National Science Foundation (NSF) Widening Implementation and Demonstration of Evidence-Based Reforms (WIDER): Faculty Learning for Outcomes and Knowledge (FLOCK) $1,499,844.00                                                                                                DUE: #134782 09/01/2014-08/31/2017                                                     Role: Faculty Core Member, Assessment for Chemistry

  3. National Institutes of Health (NIH) Bridges to Doctorate: Fresno State and UC Merced Bridges to the Doctorate Program in Biomedical and Behavioral Sciences                                                                       $1,400,000                                                                                      Role:Faculty;  PI: Krish Krishnan                                                      07/01/15-03/31/2020 NIH R25 GM115293-01

Completed Funding

NSF: Major Research Instrumentation (MRI): Acquisition of a High-Speed Camera System to Record Animal Movements in Three Dimensions.
Funded by: National Science Foundation
$311,414 (2008-2012)
Role: Co-Principal Investigator