Goto Research Group


Areas of Research

The Goto laboratory is focused on three major projects using fruit flies and human neuronal cultures to investigate neuronal function, oxidative stress and protein-protein interaction using biochemical, electrophysiological and locomotor behavioral methods. In particular the neurodegenerative diseases, amyotrophic lateral sclerosis-Parkinsonism dementia complex (ALS-PDC), Parkinson’s disease, and Alzheimer’s disease are investigated using fruit flies as a model system, human neuronal cultures are studied to elucidate protein-protein interactions using immunofluorescence and FRET microscoy, and oxidative stress in fruit flies and neurons are measured using traditional biochemical assays.

Recent Publications and Presentations

  1. Sinha, A. and Goto, J.J. HPLC Analysis to Quantify the Neurotoxic BMAA Levels in Fruit Fly; honorable mention San Joaquin Valley section, American Chemical Society award; 32nd Annual Central California Research Symposium (CCRS), April 6, 2011.
  2. Karanjit, A. and Goto, J.J. Two-Dimensional Gel Electrophoresis and Mass Spectrometry to Analyse Drosophila melanogaster Treated with the Neurotoxin BMAA; 32nd Annual Central California Research Symposium (CCRS), April 6, 2011.
  3. Umar, M.; Runyon, R.; Coulibaly, R.; Correa, J.; Seber, C.; Leyva, G.; Egusquiza, R.;  Ringel, J.; Xiao, M.; Bushoven, J.; Goto, J.J. The Effect of Microgravity on the Formation of Calcium Oxalate in Plant Cells; Jordan College of Ag Sciences & Technology  Research Day, May 4th, 2011.
  4. Kroeker, B.; McGinnis, L.R.; Dimes, S.; Goto, J.J. The Effects of Manganese Toxicity on Motor Activity in Drosophila melanogaster; 32nd Annual Central California Research Symposium (CCRS), April 6, 2011.
  5. Benjamin, C.J.; Kamat, S.; Muller, U.K.; Goto, J.J. Ontogenetic Changes in the Skeletal Muscle Function of Zebrafish Larvae: Identification of Biochemical Markers for Slow and Fast Contractile Behavior; 23rd Annual CSU Biotechnology Symposium (CSUPERB), Anaheim, California, January 7-8, 2011.
  6. Mekdara, N.T., Choudhury, S.; Mekdara, P.J.; Goodarzi, A.; Mazloomi, F.; Adam, M.; Berg, O.; Goto, J.J.; Muller, U.K. Exploring the Effects of the Glutamate Agonist BMAA on Central and Peripheral Motor Control in Drosophila melanogaster; Society of Integrative and Comparative Biology (SICB) Annual Meeting, Salt Lake City, Utah January 3-7, 2011.
  7. Goto, J.J. The Neuronal Effects of BMAA on the Electrophysiology and Locomotion of Fruit Flies, The Klara Farkas International Conference on Plant Medicine; Invited Talk; Jackson Hole, Wyoming, October 11-15, 2010.

Current Funding

  1. NSF: Major Research Instrumentation (MRI): Acquisition of a High-Speed Camera System to Record Animal Movements in Three Dimensions.
    Funded by: National Science Foundation
    $311,414 (2008-2012)
    Role: Co-Principle Investigator

  2. California State University, Fresno
    Research, Scholarship and Creative Activities Award
    A Biochemical Approach to Alleviate Neurodegenerative Disease
    $5,000 (2011-2012)
    Role: PI
  3. California State University, Fresno
    Division of Graduate Studies & Division of Undergraduate Studies
    Faculty Student Research Awards (Supporting 6 undergraduate & 5 graduate research students)
    $16,000 (2011-2012)
    Role: PI
  4. Jan & Bud Richter Center for Community Engagement and Service-Learning
    Laying the Foundation for Service Learning in STEM Disciplines Grant
    $2,000 (2011)