Joy J. Goto , Ph.D.
Office Location: Science Building Room 366
Office Phone: 559.278.2530
Joy J. Goto earned a B.S. in Chemistry from UC Davis and Ph.D. in Chemistry from UCLA. She was the recipient of the UCLA Alumni Association distinguished dissertation year award and a Collegium of University Teaching fellowship. Dr. Goto was a John Douglas French Alzheimer s Foundation research fellow in the Genetics and Aging Research Unit at the Center for Aging, Genetics, and Neurodegeneration at Harvard Medical School and a Beckman Senior Research Fellow in the Neurosciences Division at the City of Hope Beckman Research Institute in Duarte, Calfiornia. She was a visiting Assistant Professor of chemistry in the Joint Science Department of Scripps, Claremont McKenna and Pitzer Colleges prior to joining Fresno State in 2007. Dr. Goto uses her training in bioinorganic chemistry and neuroscience to contribute to the understanding of neurodegenerative diseases, oxidative stress and metal homeostasis.
Areas of Specialty
The Goto laboratory is focused on three majors projects using fruit flies or human neuronal cultures to investigate neurochemical functions and neuromuscular electrophysiology and behavior as a model for neurodegenerative disease and oxidative stress. Project 1: Amyotrophic lateral sclerosis – Parkinsonism dementia complex (ALS-PDC) is one such disease her lab investigates, where a non-natural amino acid produced by cyanobacteria is implicated in the progression of ALS-PDC. Proteomic, electrophysiological and behavioral experiments are conducted to investigate this fruit fly model of the disease. Project 2: The interaction of specific proteins involved in the abnormal proteolytic processing in Alzheimer’s Disease is investigated using coimmunoprecipitation and RIMI facility microscopy. Project 3: Oxidative stress and transition metal ion homeostasis is investigated in fruit flies as a model of aging.
Teaching and Mentoring
Dr. Goto teaches courses from general chemistry laboratory (Chem 1BL) to upper-division biochemistry (Chem 150, 153, 155). She has an adjunct position with the Department of Biology and teaches Chemistry/Biology 242 (Techniques in Protein Purification and Analysis) and Bio 166 (Neurophysiology). Her interdisciplinary background reflects itself in her research and teaching. The undergraduate and graduate students working on research projects in Dr. Goto’s laboratory have been from diverse academic fields including chemistry, biology, biotechnology, publich health and psychology. Dr. Goto is currently the facult co-advisor for the Fresno State Chemistry Club and advisor for the American Medical Student Association (AMSA); she is also pre-pharmacy advisor for the Chemistry Deparment.