Cory L. Brooks, Ph.D.
Dr. Brooks earned his Ph.D. in Biochemistry and Microbiology from the University of Victoria in Canada where his thesis work focused on the structures of carbohydrate-specific germline antibodies. His post-doctoral research was conducted at the University of Alberta, Canada in the field of membrane protein structural biology. He joined the chemistry faculty at Fresno State in 2013.
Areas of Specialty
1. Single domain antibodies for the detection and neutralization of Listeria monocytogenes
This research project involves the use of a special class of antibodies called single domain antibodies (sdAbs) that are derived from Camelid species. These sdAbs have unique binding properties, high stability and ease of recombinant production rendering them ideal therapeutics. We are studying the structures of these antibodies to understand how they can be used to develop novel biosensors and prophylactic therapies for the detection and prevention of the food borne pathogen Listeria monocytogenes.
2. Therapeutic antibodies targeting cancer specific glycoproteins
Abnormal glycosylation of cell surface proteins is a universal feature of cancers. These tumor-associated changes permit specific targeting of cancer cells by antibodies, representing an exciting therapeutic avenue. We are exploring the structures of therapeutic antibodies targeting a class of proteins called MUCINS, to better understand how they bind their antigens. The information from these structures is being used to engineer and improve therapies for breast and pancreatic cancer.