• Overview
• Facilities
• Biological and Biophysical Chemistry
  • Laurent Dejean
  • Melissa Golden
  • Joy Goto
  • Krish Krishnan
  • Santanu Maitra
• Environmental and Applied Chemistry
  • Alam Hasson
  • Eric Person
• Nanochemistry and Measurements
  • Jai-Pil Choi
  • Kin Ng
• Synthesis and Catalysis
  • Saeed Attar
  • Melissa Golden
  • Santanu Maitra
• Get Involved
• Alphabetical Index

Krishnan Research Group

Website:

zimmer.csufresno.edu/~vkrishnan

Areas of Research

Our overall research interests are twofold: Structural and computational biophysical chemistry with specific emphasis on molecular biophysics methods (high-resolution biomolecular NMR, Circular Dichroism (CD) and Differential Scanning Calorimerty (DSC)). Currently our focus is on understanding the underlying molecular functional dynamics of and conformational distribution of intrinsically disordered proteins (IDPs), such as nucleoporins and antifreeze glycoproteins.

The second area of research is in applied biostatistics and bioinformatics for biomedical research. In particular we collaborate extensively with biomedical scientists and clinicians to identify molecular biomarkers using functional genomics, proteomics as well as metabolomics.

Recent Publications

1. V.V.Krishnan, I.H. Khan and P.A. Luciw, Biomarker detection and molecular profiling by multiplex microbead suspension array bead immunoproteomics, Molecular analysis and Genome Discovery (in press).
   
2. R. Ravindran, I.H. Khan, V.V. Krishnan et al., Multivariate analysis of large volume multiplex serodection in mouse model for infectious disease. Journal of Immunological Methods 363, 51-9 (2011).
   
3. E. Reese and V.V. Krishnan, Classification of DNA sequences from thermal melting profiles, Bioinformation, 4, 463-467(2010).
   
4. V.V. Krishnan, I.H. Khan and P.A. Luciw, Multiplexed microbead immunoassays by flow cytometry for molecular profiling: Basic concepts and proteomics applications, Critical Reviews in Biotechnology, 29, 29-43 (2009).
   
5. I.H. Khan, V.V. Krishnan (equal contribution with first author),  M. Ziman, K. Janatpour, T. Wun, P.A. Luciw and J. Tuscano, (2008) Comparison of multiplex suspension array large panel kits for profiling cytokines and chemokines in rheumatoid arthritis patients, Cytometry Part B, 76, 159-168 (2009) Cover Article.

Current Funding

1. Developing Biomedical Research Infrastructure for California’s Central Valley (PI: Provost Covino)
   Role: Research Director and co-PI, Sept 2007 – July 2012 (NIH/NIGMS)
2. Fresno State-SBCC Partnership: Cancer Research and Training for Central California (PI: Associate Provost: Junn)
   Role: Co-PI, Jul 2010-Aug 2013 (National Cancer Institute)